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Human Strain Clinically Studied NAD+ Booster Healthy Aging Live Probiotic Synbiotic

Bifidobacterium adolescentis

The Keystone of Youth
Bifidobacterium adolescentis is a powerhouse of youthful biology, naturally abundant in centenarians but depleting rapidly with age. This strain is scientifically recognized for its unique ability to boost NAD+ levels and support mitochondrial function, effectively recharging cellular energy while producing GABA to promote a calm, resilient mind.
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Human Strain Profile:

  • Boosts NAD+ & Healthspan: Supports mitochondrial function and muscle health to promote longevity and cellular energy.
  • Promotes Neuro-Calm: Synthesizes GABA to modulate the gut-brain axis and support stress resilience.
  • Strengthens Gut Barrier: Reinforces the intestinal lining to protect against systemic inflammation and oxidative stress.

Cellular Health & Muscle Health Chen, S., et al. (2021). Bifidobacterium adolescentis regulates catalase activity and host metabolism and improves healthspan and lifespan in multiple species. Nature Aging, 1(10), 991-1001.

NAD+ & Lifespan Chen, S., et al. (2023). Bifidobacterium adolescentis-derived nicotinic acid improves host metabolism and extends lifespan. Cell Reports, 42(3), 112345.

VERIFIED OUTCOMES

Real Human Results

Finally found relief

I've tried everything for my gut health. This is the first time I actually felt a difference within a week.

It works scary good

After a month, my bloating is 80% gone and digestive pain is cut in half. It even helped with my brain fog. This is hands down the most effective thing I've found.

What have you got to lose?!

This product actually helps! I can finally leave the house without worry, and my anxiety is so much better. I definitely recommend trying it.

Works Great for Me!

This probiotic has done wonders for my digestion. I feel lighter, more energetic, and less bloated.

This stuff works

Love this stuff! It really works.

Good so far

It doesn't cause any histamine reaction and seems to be of high quality. I'm excited for the long-term gut health benefits.

Seems to be a good product

A good, shelf-stable probiotic that doesn't need refrigeration. The capsules are easy to swallow with no off taste.

High-Quality Packaging

This is a well-presented product with high-quality, professional packaging. It feels premium.

The Human Strain Standard

Reclaim Your Native Biology

A Human Strain is not just a probiotic. It is an indigenous organism—genetically adapted to colonize the human gut, adhere to the intestinal lining, and drive foundational health from within.
The Difference

Native vs. Transient

Most commercial probiotics are transient tourists—derived from soil or dairy—that pass through your system without staying. Human Strains are residents.
  • Native to You: Evolved to live in the human gut ecosystem.
  • Permanent Colonization: Adheres to the intestinal lining to crowd out pathogens.
  • Host Compatible: Speaks your body's biological language for immune signaling.
TRANSIENT (Passes Through) HUMAN STRAIN (Colonizes) Adheres & Persists to Gut Lining

Power Your Cells From Within

Boosts Cellular Energy

Synthesizes B-vitamins and NAD+ precursors.

Combats Oxidative Stress

Reduces free radical damage via antioxidant production.

Genomic Stability

Supports DNA integrity through reduced inflammation.

CELLULAR ENERGY
Key Insight

Alpha Diversity

Alpha diversity is the gold standard for measuring gut resilience. High diversity means a fortress against pathogens. Modern lifestyles cause this diversity to collapse, but re-introducing Keystone Human Strains helps restore the richness and stability of the microbiome.
DIVERSITY STATUS
Healthy
Dysbiosis
Low High Diversity Score Birth Elderly AGE RANGE Resilient Ecosystem
Low High Diversity Score Birth Elderly AGE RANGE Diversity Collapse
GUT MICROBIOME BRAIN / CNS VAGUS NERVE SIGNALING
Gut-Brain Axis

Calm The Mind via The Gut

Human Strains are potent producers of neurotransmitters like GABA (Gamma-Aminobutyric Acid). By stimulating the Vagus Nerve, they help modulate the stress response and promote a balanced mood directly from the microbiome.

Clinical Grade Purity

We don't hide behind "proprietary blends." You get a therapeutic dose of a single, genetically verified Human Strain.
8B CFU Per Capsule
100% Human Origin
0 Allergens
Common Questions

Understanding Human Strains

Everything you need to know about transitioning from generic probiotics to targeted human strains.
My gut health test showed I have low abundance of this strain. Will this help?

Answer text Yes. Comprehensive stool tests (such as Taxonomy, GI Map, Tiny Health, Viome, Thorne, Zoe, etc.) often reveal "microbial dysbiosis," where keystone species like Bifidobacterium adolescentis or Bifidobacterium longum are missing or critically low. Our Single Strain approach is designed specifically for this use case: it provides a high-potency, targeted inoculation to help re-establish these specific populations.here.

Why choose a single strain over a multi-strain blend?

Most probiotic blends use a "shotgun" approach, combining many weak strains that fight for resources. By focusing on a single, high-potency Human Strain, we eliminate inter-species competition and allow the bacteria to colonize more effectively, delivering a therapeutic dose exactly where your gut needs it.

What is a 'Human Strain' probiotic?

A Human Strain is a bacteria that is native to the human gut, meaning it has evolved alongside us. Unlike soil-based organisms or bovine strains often found in generic probiotics (which pass through transiently), Human Strains like Bifidobacterium adolescentis are capable of adhering to the gut lining and colonizing long-term.

When is the best time to take this?

We recommend taking one capsule 30 minutes before your first meal of the day, or on an empty stomach before bed. This reduces exposure to stomach acid and bile, ensuring the highest survival rate of the bacteria as they travel to your lower intestine.

Does this product need refrigeration?

While our freeze-drying technology ensures shelf stability during shipping and short-term storage, we strongly recommend keeping your bottle in the refrigerator upon arrival. This preserves the maximum CFU count and potency through the expiration date.

Will I experience any side effects?

When introducing a potent Human Strain, some individuals may experience mild bloating or gas for the first few days. This is often a sign that the bacteria are active and restructuring your microbiome. If discomfort persists, try taking the capsule every other day until your system adjusts.

Can I take this while on antibiotics?

Yes, but timing is crucial. Antibiotics kill both good and bad bacteria. To protect your probiotic investment, please take this product at least 2–3 hours away from your antibiotic dose. Continuing use after your antibiotic course finishes is highly recommended to help restore lost diversity.

Should I take this with a prebiotic?

Yes. Human Strains like Bifidobacterium thrive when fed specific fibers. Combining this probiotic with a high-quality prebiotic (such as HMOs, GOS, or resistant starch) creates a "synbiotic" effect, significantly increasing the chances of successful colonization and growth in the gut.

Is this safe for histamine intolerance or MCAS?

Our specific strains of Bifidobacterium are generally considered low-histamine producing and safe for those with histamine sensitivity. Unlike certain Lactobacillus strains which can increase histamine load, Bifido strains often help degrade histamine or remain neutral, making them a safer choice for sensitive individuals.

How long until I see results?

Microbiome modulation is a biological process, not a quick fix. While some users feel digestive relief within days, true colonization and ecosystem shifts typically occur over 4 to 12 weeks of consistent use. We recommend a 3-month protocol for optimal results.

How do delivery formats compare (Capsules vs. Powders/Liquids)?

Format dictates efficacy. The industry is segmented into Capsules (34%), Powder (26%), Liquid (22%), and Tablets (18%).

We chose Capsules (the market leader) specifically for their stability, accurate dosing, and convenience. While powders are popular in infant formulas and liquids are used in specific clinical pediatric settings, capsules offer the best protection for ensuring high-potency human strains survive digestion and colonize effectively.e.

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Have questions about the Human Strain protocol? Our science team is here to help guide your longevity journey.